CALL FOR PAPERS Nanoparticles and the Lung: Friend or Foe? Pulmonary instillation of MWCNT increases lung permeability, decreases gp130 expression in the lungs, and initiates cardiovascular IL-6 transsignaling
نویسندگان
چکیده
Leslie C. Thompson,* Nathan A. Holland,* Ryan J. Snyder, Bin Luo, Daniel P. Becak, Jillian T. Odom, Benjamin S. Harrison, Jared M. Brown, Kymberly M. Gowdy, and Christopher J. Wingard Department of Physiology, Brody School of Medicine at East Carolina University, Greenville, North Carolina; Department of Pharmacology & Toxicology, Brody School of Medicine at East Carolina University, Greenville, North Carolina; NanoHealth Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina; and Wake Forest University Institute of Regenerative Medicine, Winston-Salem, North Carolina
منابع مشابه
Protective Effect of Grape Seed Extract against the Fibrogenic Effect of Bleomycin in Rat Lung
Many studies have been performed for treatment or prevention of pulmonary fibrosis. However, no effective treatment has been found yet. The aim of this study was to investigate the effect of grape seed extract on bleomycin-induced lung fibrosis in rat. Hydroalcoholic extract of grape seed (Vitis vinifera) was prepared using maceration method. NMRI rats weighing 250-300 g were given...
متن کاملDevelopmental changes in Endothelin-1 and Endothelin type A receptor expression in the lungs of chickens (Broiler versus layer)
Background: Broilers lung mechanisms that regulate endothelin (ET) in the lung are complex and poorly understood. Objectives: Methods: In this experiment lung ET-1 mRNA levels and lung mRNA expression for the ET(A) receptors were determined in lung tissue weekly (term = 42 days, intervals = 7 days). Serum endothelin concentration was also measured at these ages. Results: The study showed that e...
متن کاملThe role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
BACKGROUND Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products of manufacture or the environment, have been associated with granulomatous disease. This paper utilizes a previously described carbon nanoparticle granuloma model to address th...
متن کاملModulation of cellular transport characteristics of the human lung alveolar epithelia
Among the drug delivery and targeting (DDT) routes, lung alveolar epithelium has been given enormous attentions in terms of the delivery of a wide range of macromolecules such as gene- or protein-based nanopharmaceuticals. However, little is known about cellular modulation of lung transport characteristics by endogenous and/or exogenous agents. Thus, in the current study, impact of dexamethason...
متن کاملThe Role of EDD (Exercise Capacity, Dyspnea, and Diffusing Capacity of Lungs for Carbon Monoxide) Index in Pulmonary Fibrosis Secondary to Scleroderma
Introduction: Pulmonary involvement secondary to Systemic Sclerosis (SSc) is the major cause of morbidity and mortality in SSc patients. We designed this study to determine the correlation of important lung function parameters with lung High Resolution CT (HRCT) scan findings. Materials and Methods: Thirty–two consecutive diffuse SSc patients with pulmonary fibrosis were enrolled in this cross...
متن کامل